Based on the description above
Select/name one of the diseases/conditions Mary-Lou is suffering from and describe two signs and/or symptoms from Mary-Lou’s history that support your selection.
Explain the pathophysiology of the condition you named
Explain the mechanism of action of one drug type Mary-Lou is prescribed with and describe how these drug actions help mitigate some of her symptoms. In you answer, make references to the pathophysiology of the relevant disease and relate the chosen drug’s mechanism of action to the aetiology/pathogenesis of the disease.
The following questions relate to a drug called MedZ:
a. MedZ contains 200 mg of the active ingredient in an intestine-solvent capsule. The active ingredient is effectively transported across the intestinal mucosa, which ensures that 78% of the drug is absorbed and enters the portal circulation. The drug undergoes a significant degree of first-pass metabolism, in which process 55% of the drug passing through the liver gets metabolized and therefore degraded to an inactive product. Calculate MedZ’s bioavailability and show your calculations
b. When administered alone, 82% of MedZ is bound to plasma albumin. However, because of the higher plasma protein binding affinity of another drug, called MedY, when MedZ and MedY are administered together, the bound fraction of MedZ decreases to 35%.
i. Identify the type of drug interaction between MedZ and MedY in the present scenario and give your rationale.
ii. Assuming that MedZ and MedY are administered together in an elderly patient, explain if the dose of MedZ should be decreased, increased, or left unchanged and give your rationale.
Name the disease affecting Mary-Lou’s left knee and describe two characteristic clinical manifestations of this pathology (2 mark). Explain the aetiology and pathophysiology of the disease.
Considering Mary-Lou’s T-score, identify the disease she suffers from, briefly describe the pathogenesis of this disease, describe the mechanism of action of bisphosphonate administration, and explain the benefits of this treatment in her present condition.
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